MRI Findings of Organophosphate Poisoning Encephalopathy During Recovery Phase

Objective:To study the MRI characteristics of organophosphate poisoning encephalopathy during recovery phase.Methods:Clinical symptoms and MRI findings of 4 cases with severe organophosphate poisoning encephalopathy during recovery phase were reviewed in order to study the changes of brain structures.Results:Of the 4 cases with organophosphate poisoning encephalopathy,positive bilateral Babinski sign and mild abnormal EEG were presented clinically.The abnormal MRI findings included long T1 and long T2 signal intensities of cerebellum and midbrain (n=1),short T1 and long T2 signal intensities in bilateral caudate nucleus and putamen symmetrically (n=1).long T1 and long T2 signal intensities in bilateral caudate nucleus,putamen and globus pallidus with ventriculomegaly and cerebellar atrophy (n=1),bilateral and symmetrical abnormal signal intensities in caudate nucleus,putamen and globus pallidus,with ventriculomegaly and the atrophy of medial gyrus of bilateral occipital lobe,brain stem and cerebellum,the atrophic cerebellum showed high signal intensity on T1WI (n=1).Conclusion:The MRI findings of organophosphate poisoning encephalopathy during recovery phase mainly involved the caudate nucleus,putamen,globus,pallidus,thalamus,midbrain and cerebellum encephalo-malacia within brain cortex and brain atrophy might be showed in severe cases.

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